Lois lives at 31 Spooner Street with her family and also Brian , the anthropomorphic family dog. Lois is voiced by Alex Borstein. At the time series creator Seth MacFarlane approached her for a role on the show, she was doing a live stage show in Los Angeles, playing a redhead mother in a sketch. The voice style was modeled after one of her cousins' voice.
Lois has a long lost brother named Carl, who in one episode, is revealed to be a serial killer that kills fat people. Lois Griffin married Peter because she was attracted to him due to his silliness and social class. Many episodes show that Lois Griffin is a very neglectful and irresponsible parent towards Meg and Chris , and eventually behaves the same with her youngest child Stewie. Lois Griffin and Meg Griffin have the same nose and mouth but somehow Meg is considered ugly while Lois is smoking hot. Lois had an affair with a man named Stan Thompson, which resulted in the birth of Meg. There are several episodes of Family Guy that portray Lois as a bisexual. Lois has two other children before her current three.
She is voiced by writer Alex Borstein and first appeared on television, along with the rest of the Griffin family , in the minute short on December 20, Lois was created and designed by series creator Seth MacFarlane. MacFarlane was asked to pitch a pilot to the Fox Broadcasting Company based on Larry and Steve , a short he made which featured a middle-aged character named Larry and an intellectual dog, Steve.